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The pathophysiology of ischaemic stroke is defined by the limitation of oxygen supply (hypoxia or anoxia), and restricted supply of metabolic substrates

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Its important to distinguish this rule from the printed expiration date on the vial

GRP78, also known as immunoglobulin heavy chain binding protein (BIP), is one of the main chaperone proteins in the endoplasmic reticulum (ER) (Wei et al., 2012)

They are opportunistic pathogens able to cause serious and sometimes fatal infections in humans and other animals