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Acknowledgements This study was supported by the Bio & Medical Technology Development Program of the National Research Foundation of Korea (NRF- 2022M3E5E8081191 to C.-K.P.) and (NRF- 2021R1A5A2030333 to Y.H.K.), both of which are funded by the Korean government

In patients already receiving an opioid analgesic, prescribe a lower initial dose of the benzodiazepine or other CNS depressant than indicated in the absence of an opioid, and titrate based on clinical response

As emphasized, BPC 157 rats regularly did not show the liver and lung congestion, lung hemorrhage and hepatocyte damage or heart tissue congestion or kidney lesions