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The observed changes in plasma alanine and glucagon concentrations with survodutide but not placebo or semaglutide indicate target engagement at both the GCGR and the GLP-1R, highlighting that survodutide is a GCGR/GLP-1R dual agonist and its effects are exerted at both receptors

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This allows each cell to produce exactly what is needed to restore its specific redox balance without risking the over-suppression of beneficial, low-level ROS signaling that is absolutely necessary for normal cellular function and immune defense

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Biomolecules 13 , 586 (2023)