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In a randomized controlled trial, rifaximin attenuates gut-derived systemic inflammation by suppressing oralization-associated, mucin-degrading sialidase-rich species (e.g., Streptococcus and Veillonella ) and promoting a barrier-repairing intestinal environment [126]

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GHK-based formulations, including nanoparticle conjugates, hydrogels, and clinical derivatives such as TriHex and TriHex 2.0, enhance fibroblast migration, ECM remodeling, collagen and elastin synthesis, and wound closure while providing antimicrobial activity

5-Aminosalicylic acid ameliorates colitis and checks dysbiotic Escherichia coli expansion by activating PPAR- signaling in the intestinal epithelium