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doi: 10.1007/s12031-019-1257-9 214 Long-SmithCMManningSMcCleanPLCoakleyMFOHalloranDJHolscherCet al

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However, Janeway and colleagues first observed that B10.PL mice lacking B cells suffered an unusually severe and chronic form of EAE, suggesting that anti-inflammatory B cells in charge of negatively regulating inflammatory reactions may be depleted (Wolf et al., 1996)