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Clinical studies Compared with the considerable amount of pre-clinical and mechanistic research reported above, we identified few clinical studies of GLP-1RAs for substance-use disorders (Table 2): three for alcohol 111,112,113 , one for cannabis 114 , two for cocaine 115,116 and two for nicotine 117,118 , while no article about opiates or amphetamines was retrieved

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However, as their reputation grows, so do the questions surrounding their outcomes, especially at the hormone levels

Pregnancy, breastfeeding, kidney disease, severe anemia, and neurologic symptoms may require closer follow-up

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