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Generation and maintenance of epithelial polarity The initial cues for the generation of epithelial polarity are provided by epithelial cell-cell contacts and extracellular matrix proteins, which directly activate receptor-mediated signal transduction pathways and, in addition, act through mechanical forces and cell confinement

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Given the significant impact of miRNAs on gene expression and their involvement in various biological processes, the development of miRNA-based agonists or antagonists, such as antagomir-155, represents a promising novel direction for precisely modulating the immune-inflammatory interactions within this microenvironment

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