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3e was obtained after purification by column chromatography in a yield of 32.8 mg and as a racemic mixture of cis - and trans -diastereomers (0.19 mmol, 42.4%)

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It is now considered to be an active osteogenic process of vascular cells (mainly VSMCs), similar to osteoblast formation, and is defined by the stages of osteogenic differentiation, matrix maturation, and matrix mineralization (57)