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Because it works by helping regulate appetite biologically, many individuals find it easier to sustain compared to highly restrictive diets

Preparation for injection consisted of thawing the aliquots at 37C and brief sonication to ensure SG was fully solubilized

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GLP-1RAs mimic the effects of native GLP-1, but as the resulting pharmacological concentrations reach supraphysiological levels, GLP-1 RAs have been shown to exert pleiotropic effects beyond glucose control [6], such as stimulation of the activity of the hypothalamic-pituitary- adrenal axis [7,8,9,10]