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4 Primary end point: Mean change in BMI (%) from week 0 to week 68 3,4 Patients in both arms received instruction for reduced-calorie diet and increased physical activity All patients transitioned to a 7-week (weeks 68-75) off-treatment, lifestyle-therapy-only period

doi:10.1128/MCB.00544-08

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J Neurosci 27(43):1159511603 Riedlinger D, Bahra M, Boas-Knoop S, Lippert S, Bradtmller M, Guse K, Seehofer D, Bova R, Sauer IM, Neuhaus P, Koch A (2014) Hedgehog pathway as a potential treatment target in human cholangiocarcinoma