The hypothesis likely applies to many other neurological disorders, such as schizophrenia, with the major differences among disorders being the source, concentration, and reactivity of the accumulated aldehydes
10.1016/j.redox.2017.08.015 112 Mas-BarguesC.EscrivC.DromantM.BorrsC.ViaJ
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BioMed Research International , 2015.PMID: 26236730 Comprehensive review of GHK-Cu's effects on skin remodeling including collagen synthesis, glycosaminoglycan production, and growth factor expression
Overall, across the two repeat experiments for Cagri and CagriBB bound to the CTR, the conformational equilibrium between the bypass vs CT-like state was similar, suggesting that the salt bridge/ionic lock is sufficient to preferentially stabilize the bypass conformation at CTR (Supplementary Fig