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Previously, these treatments required patients to self-administer injections on a regular basis, which could be a barrier to adherence for many individuals

However, there is research in progress to see whether the drug has long-term effects, like damage to the thyroid or gastrointestinal tract.

The temporal pattern may differ as well, with systemic effects potentially developing more gradually or persisting beyond the immediate post-injection period

Cold sensitivity may result from loss of insulating adipose tissue and decreased basal metabolic rate during weight loss

Stimulant laxatives such as bisacodyl (Dulcolax) or senna (Senokot) are appropriate for intermittent or adjunct use