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Schmitt M, Ewendt F, Kluttig A, Mikolajczyk R, Kraus FB, Wtjen W, et al

4.2 Gut microbiota dysbiosis and abnormal activation of complement C4 Genetic susceptibility to schizophrenia is significantly associated with polymorphisms in genes related to the complement system, largely attributable to alleles of the complement C4 gene located within the major histocompatibility complex region on chromosome 6 (132)

I get asked about these every single week in clinic

By day 3-4 of multi-dose use, microbial contamination becomes likely

When that framework is missing, even the best-researched combination can underperform or create unnecessary frustration