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This inverse relationship is why a low TSH on tirzepatide can indicate levothyroxine overmedication, your body is absorbing more thyroid hormone than intended, so the pituitary reduces TSH production

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[DOI] [PMC free article] [PubMed] [Google Scholar] 239.Schreiber R, Hofer P, Taschler U, Voshol PJ, Rechberger GN, Kotzbeck P, et al

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