In a primary culture of orbital fibroblasts from GO patients and control subjects treated with H 2 O 2 to induce OS, the antioxidants vitamin C, N-acetyl-L-cysteine, melatonin, retinol, -carotene and vitamin E were found to reduce the manifestations OS (proliferation of fibroblasts, the level of hyaluronic acid, the level of tumor necrosis factor- (TNF-), IFN- and IL1-, which provided the basis for the possible clinical use of these substances in patients with GO (87)
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Ferroptosis: Role of lipid peroxidation, iron and ferritinophagy
Future studies whenever feasible might continue to explore heterogeneity of treatment effects of GLP1 receptor agonists or SGLT2 inhibitors, especially in clinically relevant subgroups, across BMI strata, and across age strata, which may suggest opportunities to optimize personalized dementia risk mitigation based on risk profiles