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Diagnostic modalities utilizing CRCs altered metabolism such as 18F-fluorodeoxyglucose positron emission tomography (18F-FDG PET/CT) and metabolomic analysis of circulating metabolites, improved early detection through enhanced sensitivity and specificity

The phase 2 data suggest that if the priority is body weight reduction in obesity without diabetes, higher dosing arms like 12 mg may be appropriate for exploration

Conversely, for those who struggle primarily with brain fog and fatigue during the day, a morning dose may be more beneficial

Both drugs also led to significant reductions in liver enzymes and blood lipid levels, with varying effects on serum TG and TC in the diet-restricted groups (Fig.4-E, F, G, H)

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