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For muscle cramping, clinicians should first assess for electrolyte abnormalities, including magnesium, calcium, and potassium, before considering supplementation

This means they must be converted to L-ascorbic acid before theyre of use to the skin

Close medical monitoring remains important

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Contraception is also recommended for women of child-bearing age using GLP-1s because of safety concerns raised by animal studies linking exposure of the medication during pregnancy to reduced foetal growth, slowed bone development and reduced maternal weight gain