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[92] A one-carbon (1C) methyl group is added to tetrahydrofolate through the action of serine hydroxymethyltransferase (SHMT) to yield 5,10-methylenetetrahydrofolate (5,10-CH 2 -THF)

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Notably, two patients with severe AD exhibited particularly low vitamin C levels of 8.24 and 12.30 mol/L

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