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Hyperglycemia induces trained immunity in macrophages and their precursors and promotes atherosclerosis

Pfeffer MA, Claggett B, Diaz R, Dickstein K, Gerstein HC, Kber LV, Lawson FC, Ping L, Wei X, Lewis EF, et al

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Sci Rep 10 , 13566 (2020)

Our results suggest that prolonged fasting between meals is an essential component of the benefits of CR on the development and progression of AD in mice