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This effect appeared to be mediated by antioxidant mechanisms involving GSK3 phosphorylation 156 , and it was also associated with a reduction of measures of memory impairment in mice 157

Research shows that MTHFR gene mutations can affect folate metabolism and methylation, two processes vital for DNA repair, hormone balance, detoxification, mental health, and fertility

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Some antioxidants, for example, may theoretically interfere with the controlled oxidative environment that supports certain stages of follicular development