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It is recommended to apply at night time before going to bed

Melatonin regulates animal reproductive activities mainly through the hypothalamuspituitarygonad axis and through membrane binding receptor (MT1 and MT2) interactions

Precision Signaling for Clinical Longevity Healthgevity is advancing a new standard in healthspan optimization through precision signaling nutrition

Taking both together makes sense for most people, though folate status should be adequate before starting high-dose b12 to avoid masking folate deficiency