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Mitochondrial cascade hypothesis Mitochondrial dysfunction and the accumulation of reactive oxygen species lead to neuronal damage and ultimately contribute to the pathogenesis of neurodegenerative diseases, particularly AD

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Infants are especially vulnerable to metal poisoning because they are poor excretors due to low production of glutathione [2], and because they are usually on all-milk diets, which decreased mercury excretion by a factor of three in a study of rats [3]