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If glucose levels remain uncontrolled with metformin and SGLT2 inhibitors, adding a GLP-1 receptor agonist is recommended (Figure S5) [107, 111]

Rinaman explained that when GLP-1R agonist drugs are given systemically, they are not recruiting the central GLP-1 endogenous neurons but are accessing a subset of the receptors

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Several GLP-1 receptor agonists are currently available in the UK, though their primary licensed indications are for type 2 diabetes and, in some cases, weight management

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