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Structure of the MDM2 oncoprotein bound to the p53 tumor suppressor transactivation domain

Memantine, a clinically well-tolerated NMDAR antagonist with low affinity and rapid off-rate kinetics, can selectively block open channels and mitigate excitotoxicity while preserving normal glutamatergic transmission [202]

K.Voyno-YasenetskayaT

Glutathione c th lm chm tc lo ha da 2

The free radicals generated during oxidative stress include non-free radical species like hydrogen peroxide (H 2 O 2 ) and nitrous acid, as well as different forms of activated oxygen and nitrogen such as superoxide anion (O 2 ), hydroxyl, and nitric oxide (NO) radicals (Marra et al