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As with any medication, semaglutide is associated with a range of side effects

The dual action of Tirzepatide effectively reduces caloric intake while improving glucose metabolism, which explains why the SURMOUNT-1 trial data showed up to a 22.5% mean weight reduction at the 72-week mark

"A systematic review, meta-analysis and meta-regression of protein intake in resistance-trained individuals." British Journal of Sports Medicine , 52(6), 376-384

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Discontinuation rates due to adverse events were 12.2% at the 9 mg dose and 18.2% at the 12 mg dose in TRIUMPH-4