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10.1002/hipo.20482 Hippocampus 124 LiuY.-P.TungC.-S.LinP.-J.WanF.-J

primary metabolic transformation occurs in intestinal microbiota Bacterial trimethylamine (TMA) formation from excess dietary L-carnitine, subsequently oxidized to TMAO in liver Renal excretion: primary elimination route with efficient tubular reabsorption via OCTN2 Urinary excretion increases proportionally with plasma concentrations above renal threshold Plasma half-life: ~15 hours with normal renal function Elimination half-life extended in renal insufficiency These pharmacokinetic characteristics inform research protocol design, particularly regarding administration regimens, tissue sampling timepoints, and expected tissue concentrations in experimental models

[DOI] [PubMed] [Google Scholar] 226.Field DT, Cracknell RO, Eastwood JR, Scarfe P, Williams CM, Zheng Y, Tavassoli T