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First, healthy-user bias is a major concern: individuals prescribed newer, more expensive agents such as semaglutide may systematically differ from comparator groups in terms of health behaviors, dietary patterns, physical activity, adherence to medical care, and access to healthcare resources

Update of the National Surgical Adjuvant Breast and Bowel Project Study of Tamoxifen and Raloxifene (STAR) P-2 Trial: Preventing breast cancer

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