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70 There are three principle challenges associated with anti-IGF-1R hormonal therapy: (1) most of the anti-IGF-1R antibodies are reported to have minor responses, 86 (2) the therapy targeting IGF-1R causes hyperglycemia due either to disruption of GH homeostasis or direct inhibition of IR by TKIs, 87 and (3) chronic exposure to anti-IGF-1R might induce resistance

Wehinger A, Tancevski I, Schgoer W, Eller P, Hochegger K, Morak M, Hermetter A, Ritsch A, Patsch J, Foeger B

Common Side Effects Mild scalp irritation: Some users experience temporary tingling, slight burning, or redness immediately after application