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Specific statistical analysis is detailed in figure legends

Bioequivalence Analysis For EMA bioequivalence analysis, co-primary endpoints were log-transformed and analysed separately using an analysis of variance (ANOVA) model with treatment (2G oral semaglutide or 1G oral semaglutide), period (PK-sampling visits), sequence (starting with 2G oral semaglutide or 1G oral semaglutide) and participant nested within sequence as fixed effects

The most common forms are softgels, capsules, caplets, and tablets

While the calculator does not assign different values for male or female research subjects, it helps illustrate how dosing can be structured and replicated

Less tyrosinase activity means less melanin, which can gradually lead to a lighter, more even tone