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The expressions of other types of mRNAs of osteogenic genes, such as osteopontin (OPN), osteocalcin (OCN), collagen type I (COL I) and Runt-related transcription factor 2 (RUNX 2), were also upregulated to varied extents in mBMSCs after ZMTP treatment

Once there exists an accumulation of DAMPs, it would trigger the amplification of tissue inflammation, leading to more severe inflammation and CD, forming a vicious circle and disrupting the normal physiological function of tissues and organs (Linkermann et al., 2014

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However, due to its mechanism of blocking VLDL lipidation and secretion, which can cause hepatic TG accumulation, the Federal Drug Administration (FDA) issued a black box warning for hepatotoxicity, and the European Medicines Agency (EMA) did not approve use of mipomersen