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A patient with a high BMI may meet more than one pathway (for example, BMI 38 with prior stroke meets Tier 1 by BMI alone and Tier 3 by stroke), and that overlap is fine

Inhibition of transcription factor NF-kappaB reduces matrix metalloproteinase-1, -3 and -9 production by vascular smooth muscle cells

Reduced H3K27me3 expression is common in nodular melanomas of childhood associated with congenital melanocytic nevi but not in proliferative nodules

Whether depletion of specific key nutrients, including vitamins (eg vitamin D or vitamin K) could result in the specific bone and visceral effects remains unclear from the data we collected in this review

They are considered long-term medications