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ROS are highly reactive radical and non-radical forms of oxygen comprising superoxide anion (O 2 ), hydrogen peroxide (H 2 O 2 ), and highly reactive hydroxyl (OH) groups that are produced during oxygen metabolism during photosynthesis, oxidative phosphorylation, and peroxisomal activity 10,11

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In the aerobic pathway, PA is transformed to protocatechuate 35,36 through cis -4,5-dihydro-4,5-dihydroxyphthalate in Gram-negative bacterium or cis -3,4-dihydro-3,4-dihydroxyphthalate and 3,4-dihydroxyphthalate in Gram-positive bacterium 35

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