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Overproduction of ROS leads to the translocation of NF-B to the cell nucleus and provides cytokine, chemokine, and growth factor genes with access to promoter regions

While we did not measure insulin levels or resistance markers (eg, HOMA-IR), previous trials have demonstrated that semaglutide improves insulin sensitivity independently of weight loss, possibly through reductions in hepatic steatosis and low-grade inflammation

Excessive sodium increases blood pressure and glomerular workload, while too little can disrupt electrolyte balance

GLP-1 RAs may also reduce the number of dermal -T cells and IL-17 mRNA expression in psoriasis plaques in patients with diabetes [13, 22]

High-fat diet exposure, regardless of induction of obesity, is associated with altered expression of genes critical to normal ovulatory function