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When topical agents or post-surgical medications are used, they may act locally on the skin to support healing or systemically to reduce pain and prevent infection

When reviewing the causality of adverse events, it is notable that the 1998 data on adverse events that were considered to be drug related (possibly, proba-bly or definitely) reveals that certain adverse events, most notably headache, occurred at higher incidence in subjects receiving placebo than in subjects receiv-ing active (Table 7.4)

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