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The results are not particularly promising, as a possible dissociation of curcumin from lanthanide(III) ions could limit the use of these compounds in the treatment of osteoporosis ( The mixed ligand-based complexes ( Zr IV -02 , Rh III -03 , Th IV -01 , UO 2 IV -01 , and UO 2 IV -02 ), including curcumin and ( E )-1-(3,4-dimethylphenyl)-2-(4-hydroxy-3-methoxycyclohex-3-en-1-ylidene)ethan-1-one exhibited different geometries and were biologically active

Therefore, despite substantial benefit/risk assessments from clinical trial data during vaccine development, it is important to investigate mechanisms of unwanted side effects from vaccination and the potential impact on specifically affected subpopulations

Overexpression of insulin receptor partially improves obese and diabetic phenotypes in db/db mice

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