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For example, exposure to physical stimuli of suprathreshold intensitysuch as heat or mechanical forces (Gong et al., 2012) as well as oxygen deprivation (Shim et al., 2025), can upregulate HSF1 expression

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Unlike approaches that mask symptoms, it addresses the root cause of age-related decline for more complete restoration

Niacinamide 5% adds a clinically proven brightening layer, reducing the transfer of melanin to the skins surface while also minimising pore appearance and strengthening the skin barrier