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For KPV and TB-500, the FDA says it has not identified adequate human exposure data for the promoted uses

That may be a rational design for local GI exposure , where systemic bioavailability may not even be the primary objective

Seiwerth, S., Sikiric, P., Grabarevic, Z., Zoricic, I., Hanzevacki, M., Ljubanovic, D., Coric, V., Konjevoda, P., Petek, M., Rucman, R., Turkovic, B., Perovic, D., Mikus, D., Jandrijevic, S., Medvidovic, M., Tadic, T., Romac, B., Kos, J., Peric, J.,

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At age 20, plasma levels average around 200 ng/mL