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This trade-off is consistent with in human evidence that sustained energetic stress can lead to progressive myelin loss even in the absence of overt axonal pathology (Ramos-Cabrer et al., 2025), suggesting that metabolic compensation may preserve short-term function at the expense of long-term myelin integrity

Medical monitoring ensures copper levels stay in safe range

Patti, G

If patients tell us about their alcohol use prior to surgery, we can treat them with medications that can reduce their risk of going into withdrawal, and well be on heightened alert if their anesthesia needs to be adjusted. Knowing this information in advance can also allow the medical team to offer the patient instructions on how to wean off alcohol ahead of surgery

Reviewing these honestly shows a recurring pattern: strong mechanistic rationale, promising preclinical data, but inconsistent or inconclusive human results