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in vitro experiments showed that SGK1 knockdown alleviated erastin-induced downregulation of Slc7a11, GPX4, GSH, and GSSG, while reducing lipid peroxidation, iron accumulation, and mitochondrial damage upregulation, suggesting that SGK1 modulates ferroptosis processes through inflammatory pathways in CHD (44)

Skeletal muscle mitochondrial remodeling in exercise and diseases

As such, IRI is a distressing issue at the beginning of organ transplantation era and impedes the recovery of organ transplanted patient

doi: 10.1016/j.cmet.2019.10.007 20 DokaEIdaTDagnellMAbikoYLuongNCBalogNet al

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