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[12] Postulated effects of glutathione on pigmentation The role of glutathione as a skin-lightening agent was an accidental discovery when skin lightening was noticed as a side effect of large doses of glutathione

Plasma glutathione levels return to baseline within 24 weeks of discontinuation, following a biphasic elimination curve driven by renal clearance and cellular turnover

A GST of the zeta class (GSTZ1-1) is involved in the metabolism of dichloroacetate 83,84