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This signal is the keystone of the hypothalamic-pituitary-gonadal (HPG) axis: it triggers the pulsatile release of GnRH, which then stimulates the secretion of LH and FSH by the pituitary gland

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It represents a surface-agnostic physicochemical reactivation approachtopography-preserving and functionally additivethat restores high surface energy and favorable surface chemistry (via decarbonization and superhydrophilicity) without altering the underlying surface architecture

Importantly, minimal regain occurred between plateau and study completion, suggesting sustained metabolic benefits