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The reduction in SLC7A5 protein levels, without a corresponding decrease in mRNA levels upon YTHDF1 knockdown, indicates that YTHDF1 could be involved in regulating the stability or translation of SLC7A5 protein

Similarly, the expression of ALX1 (Hs00232518_m1), CDH2 (Hs00983056_m1), FOXC1 (Hs00559473_s1), LAYN (Hs00379511_m1), TM4SF (Hs00371661_m1) and VCAN (Hs00171642_m1) was additionally investigated by qRTPCR analysis in A2780 and A2780/GSTP1 cells

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However, under pathophysiological conditions, especially during APAP overdose, excessive NAPQI accumulates and binds to cellular proteins, also triggering oxidative stress, leading to hepatocellular damage and the release of damage-associated molecular patterns (DAMPs), contributing to further liver injury and inflammation

doi: 10.3389/fneur.2018.00055 21 MoraisMBAguiar de SousaD