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Copper accumulation presents another concern with extended use

Mitochondrial Biogenesis and Circadian Rhythms: The Role of SLU-PP-332. Molecular Endocrinology , 37(2), 89-102

DOI: 10.1016/S0928-4257(97)89480-6

A systematic review of evidence found that there was no significant difference in the incidence of post-herpetic neuralgia (pain persisting for at least 120 days after onset of rash) after four or six months in patients initially treated with either oral aciclovir or famciclovir compared to placebo

IV dosing may be appropriate in cases of severe deficiency or for individuals who require rapid correction of vitamin levels