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Such treatment has resulted in a substantial reduction in the accumulation of amyloid- (A) plaque and an improvement in cognitive performances (99, 100)

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[40] The liver is a major target organ of GH for this process and is the principal site of IGF-1 production

Each of these membranes is made up of different lipids and intrinsic proteins (e.g., transporters) existing on the luminal and abluminal sides, that regulate movement of molecules between the blood and the brain (Van Meer and Simons, 1986

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