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doi:10.1093/biolre/ioad032 43

Wilheilm, K

Physiologically, insulin signaling via the PI3K-Akt pathway enhances mitochondrial fatty acid oxidation by promoting the activity of carnitine palmitoyltransferase 1 (CPT1), which catalyzes the conjugation of long-chain acyl-CoA to carnitine for mitochondrial import [115,116,117]

The absence of nutrient diversity, imbalanced macronutrient intake and decreased phytochemical intake can lead to a loss of gut microbial diversity, including keystone bacteria, and simultaneously increased growth of opportunistic species, contributing to subsequent dysbiosis, reduced short-chain fatty acid (SCFAs) production, and inflammation