In Vivo Assessment of Drug Interactions Effects of Sitagliptin on Other Drugs In clinical studies, as described below, sitagliptin did not meaningfully alter the pharmacokinetics of metformin, glyburide, simvastatin, rosiglitazone, warfarin, or oral contraceptives, providing in vivo evidence of a low propensity for causing drug interactions with substrates of CYP3A4, CYP2C8, CYP2C9, and organic cationic transporter (OCT)
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doi:10.1016/j.etap.2018.08.003 99
In particular, KEAP1 and NRF2 mutations are encountered in 2030% of non-small cell lung cancers (Cancer Genome Atlas Research Network 2012
and gallstone attacks or bile duct blockages
