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Oxidative stress results from an imbalance between the oxidative and antioxidant systems of cells and tissues, leading to the excessive production of oxidative free radicals and related reactive oxygen species (ROS) [11]

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One-week treatment of DIO mice with G49 induces a transient lipid overload in the liver, increases ketogenesis and FGF21 levels Due to the rapid increase (16 h) in circulating FFAs in G49-treated mice (Fig

(6) Why

As observed for neurons, beta cells are sensitive to elevated extracellular glutamate levels and show signs of secretory defects and apoptosis at high glutamate levels [122]