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Cadmium-induced hepatic and renal injury in chronically exposed rats: likely role of hepatic cadmium- metallothionein in nephrotoxicity

Early reports that Kupffer cell-induced oxidant stress and peroxynitrite formation may cause APAP-induced injury [92, 93] were questioned as the data could not be reproduced [9496], NADPH oxidase-deficient mice were not protected [97, 98] and mitochondria in centrilobular hepatocytes were identified as the main source of superoxide and peroxynitrite under these conditions [72, 99]

doi:10.1016/S0003-2697(03)00143-X

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