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The copper(II) ion participates in metalloenzyme cofactor functions, including lysyl oxidase (required for collagen cross-linking) and superoxide dismutase (SOD)

However, the conclusions should be interpreted with caution due to considerable heterogeneity across studies, limited sample size, variations in curcumin formulations and dosages, and potential publication bias

44 Its relevance in orthopaedics may lie in its ability to support cognitive recovery and psychological well-beingfactors that can improve rehabilitation and patient-reported outcomes postoperatively