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This stimulatory effect was also observed in primary cultures of human and mouse TEC when PRL (10(-7) to 10(-8) M) was applied to culture supernatants, thus suggesting that PRL could act directly on TEC

This allows KPV to directly access intracellular inflammatory pathways at nanomolar concentrations, inhibiting NF-B activation and reducing the duration of inflammatory signaling

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GABA regulates synaptic integration of newly generated neurons in the adult brain